دانلود مقاله ISI انگلیسی شماره 75221
عنوان فارسی مقاله

تمرین های فیزیکی می تواند اختلال در حافظه ترس ناشی از محرومیت مادران را معکوس کند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75221 2009 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Physical exercise can reverse the deficit in fear memory induced by maternal deprivation
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 92, Issue 3, October 2009, Pages 364–369

کلمات کلیدی
اختلال حافظه؛ محرومیت مادران؛ یادگیری
پیش نمایش مقاله
پیش نمایش مقاله تمرین های فیزیکی می تواند اختلال در حافظه ترس ناشی از محرومیت مادران را معکوس کند

چکیده انگلیسی

Maternal deprivation during the first 10 days of life induces significant behavioral alterations in rodents which persist through adulthood. Physical exercise reduces the cognitive deficits associated with pharmacologic and pathological conditions. Here we investigated whether forced physical exercise alters memory deficits caused by postnatal maternal deprivation. Male rats were divided into four groups: (1) control, (2) deprived, (3) exercised, and (4) deprived + exercised. In groups 2 and 4, pups were deprived from their mothers for 3 h/day during the first 10 days post-birth. In groups 3 and 4, from postnatal day 45 (PND-45) on, animals were submitted to forced treadmill exercise. At adulthood, animals were submitted to four different behavioral tasks: open field, Morris water maze (MWM), object recognition (OR) and inhibitory avoidance (IA). Maternal deprivation had no effect on open field behavior, but disrupted memory in the three other tasks. Physical exercise alone had no effect, except for a slight enhancement of MWM learning. Importantly, physical exercise reversed the deficit of IA and reduced the deficit of spatial memory but not that of OR seen in deprived animals. It is possible that physical exercise may counteract the influence of maternal deprivation on neurohumoral or hormonal memory modulatory systems related to stress. Indeed, the decreasing order of the effect of exercise on the memory disturbances induced by deprivation roughly follows the descending degree of stress associated with each task (IA > MWM > OR). Maternal deprivation is known to hinder hormonal mechanisms involved in coping with stress.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.