دانلود مقاله ISI انگلیسی شماره 75249
عنوان فارسی مقاله

تاثیر جنسیت و سیکل استروس بر درماندگی آموخته شده در موش

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75249 2001 12 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
The influence of gender and the estrous cycle on learned helplessness in the rat
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Biological Psychology, Volume 58, Issue 2, November 2001, Pages 147–158

کلمات کلیدی
سیکل استروس؛ افسردگی؛ مدل حیوانی؛ استرس اجتناب ناپذیر؛ زنان
پیش نمایش مقاله
پیش نمایش مقاله تاثیر جنسیت و سیکل استروس بر درماندگی آموخته شده در موش

چکیده انگلیسی

Although the etiology of clinical depression is unknown, women are more likely to suffer from major depressive disorder than men. In addition, in some women, there is a clear association between depression and specific phases of the menstrual cycle. Surprisingly little research has examined gender differences and the influences of the estrous cycle in this and other animal behavioral models of clinical depression. Learned helplessness is a valid animal model of stress-induced behavioral depression in which prior exposure to inescapable stress produces deficits in escape testing. Learned helplessness was studied in rats using an inescapable tail shock stress followed by a shuttle box test to determine escape latencies. Animals with mean escape latencies of ≥20 s after shuttle-box testing are defined as learned helpless. Males and normal cycling female rats in the estrus and diestrus II phases were studied. Female rats in the diestrus II phase had significantly higher escape latencies and exhibited a more helpless behavior than female rats in the estrus phase. Male rat escape latencies were intermediate between the two female phases. These results suggest a role for gonadal hormones in the development of stress-induced behavioral depression or ‘learned helplessness.’

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