دانلود مقاله ISI انگلیسی شماره 75437
عنوان فارسی مقاله

فعالیت آمیگدال در اختلال وسواس اجباری با ترس از آلودگی: مطالعه با توموگرافی گسیل پوزیترون آب 15 اکسیژن

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75437 2004 13 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Amygdala activity in obsessive-compulsive disorder with contamination fear: a study with oxygen-15 water positron emission tomography
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 132, Issue 3, 30 December 2004, Pages 225–237

کلمات کلیدی
آلودگی؛ آمیگدال؛ انشعابات جسم مخطط قدامی
پیش نمایش مقاله
پیش نمایش مقاله فعالیت آمیگدال در اختلال وسواس اجباری با ترس از آلودگی: مطالعه با توموگرافی گسیل پوزیترون آب 15 اکسیژن

چکیده انگلیسی

Previous imaging studies of obsessive-compulsive symptom states have implicated frontal–striatal and limbic regions in the pathophysiology of obsessive-compulsive disorder (OCD). Functional imaging studies, however, have yielded inconsistent results, presumably due to methodological differences (patient inclusion criteria, stimulus paradigm, imaging technique, and absence of control groups). In the present study, randomized presentation of contamination-related and neutral visual stimuli was used to investigate the neurophysiological correlates of contamination fear in a group of medication-free OCD patients with washing behaviors and healthy controls. A total of 21 subjects (11 OCD patients and 10 healthy controls) were scanned using H215O positron emission tomography (PET). Subjects were presented with pictures of clean and dirty surroundings and were requested to make indoor/outdoor decisions to control for attention differences. State anxiety and obsessionality were rated after each scan using visual analogue scales. Main effects of stimulus type (contamination vs. neutral) were found in bilateral occipital cortex in both groups. A significant group interaction effect was observed in the left amygdala reflecting enhanced activity in response to contamination stimuli in OCD patients. Sensitization effects were observed in the right amygdala in the OCD group; these paralleled an increase in levels of distress and obsessionality as well as a decrease in dorsolateral prefrontal activity. The findings of the present study are consistent with the hypothesis of decreased frontal–striatal control of limbic structures, specifically the amygdala, resulting in an inadequate fear response in OCD patients with contamination fear.

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