دانلود مقاله ISI انگلیسی شماره 75449
عنوان فارسی مقاله

تغییرات ناشی از استرس در دوران بارداری در سیستم های فیزیولوژیکی مرتبط با ترکیب باکتری دستگاه گوارش در بزرگسالی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75449 2015 17 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 60, October 2015, Pages 58–74

کلمات کلیدی
استرس مادر؛ باکتری دستگاه گوارش؛ کنترل تنفسی؛ عصب روده -
پیش نمایش مقاله
پیش نمایش مقاله تغییرات ناشی از استرس در دوران بارداری در سیستم های فیزیولوژیکی مرتبط با ترکیب باکتری دستگاه گوارش در بزرگسالی

چکیده انگلیسی

Early-life adverse experiences, including prenatal stress (PNS), are associated with a higher prevalence of neurodevelopmental, cardiovascular and metabolic disorders in affected offspring. Here, in a rat model of chronic PNS, we investigate the impact of late gestational stress on physiological outcomes in adulthood. Sprague-Dawley pregnant dams were subjected to repeated restraint stress from embryonic day 14 to day 20, and their male offspring were assessed at 4 months of age. PNS induced an exaggeration of the hypothalamic–pituitary–adrenal (HPA) axis response to stress, as well as an elevation of blood pressure and impairment of cognitive function. Altered respiratory control was also observed, as demonstrated by increased variability in basal respiratory frequency and abnormal frequency responses to both hypoxic and hypercapnic challenges. PNS also affected gastrointestinal neurodevelopment and function, as measured by a decrease in the innervation density of distal colon and an increase in the colonic secretory response to catecholaminergic stimulation. Finally, PNS induced long lasting alterations in the intestinal microbiota composition. 16S rRNA gene 454 pyrosequencing revealed a strong trend towards decreased numbers of bacteria in the Lactobacillus genus, accompanied by elevated abundance of the Oscillibacter, Anaerotruncus and Peptococcus genera in PNS animals. Strikingly, relative abundance of distinct bacteria genera significantly correlated with certain respiratory parameters and the responsiveness of the HPA axis to stress. Together, these findings provide novel evidence that PNS induces long-term maladaptive alterations in the gastrointestinal and respiratory systems, accompanied by hyper-responsiveness to stress and alterations in the gut microbiota.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.