دانلود مقاله ISI انگلیسی شماره 75579
عنوان فارسی مقاله

ارتباطات عصبی مهار ارادی در سندرم تورت

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75579 2014 5 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
The neural correlates of tic inhibition in Gilles de la Tourette syndrome
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 65, December 2014, Pages 297–301

کلمات کلیدی
سندرم تورت؛ مهار تیک - چپ شکنج قدامی پائین؛ تصویرسازی تشدید مغناطیسی کارکردی حالت استراحت
پیش نمایش مقاله
پیش نمایش مقاله ارتباطات عصبی مهار ارادی در سندرم تورت

چکیده انگلیسی

Tics in Gilles de la Tourette syndrome (GTS) resemble fragments of normal motor behaviour but appear in an intrusive, repetitive and context-inappropriate manner. Although tics can be voluntarily inhibited on demand, the neural correlates of this process remain unclear. 14 GTS adults without relevant comorbidities participated in this study. First, tic severity and voluntary tic inhibitory capacity were evaluated outside the scanner. Second, patients were examined with resting state functional magnetic resonance imaging (RS-fMRI) in two states, free ticcing and voluntary tic inhibition. Local synchronization of spontaneous fMRI-signal was analysed with regional homogeneity (ReHo) and differences between both states (free ticcing<tic inhibition) were contrasted. Clinical correlations of the resulting differential ReHo parameters between both states and clinical measures of tic frequency, voluntary tic inhibition and premonitory urges were also performed. ReHo of the left inferior frontal gyrus (IFG) was increased during voluntary tic inhibition compared to free ticcing. ReHo increases were positively correlated with participants׳ ability to inhibit their tics during scanning sessions but also outside the scanner. There was no correlation with ratings of premonitory urges. Voluntary tic inhibition is associated with increased ReHo of the left IFG. Premonitory urges are unrelated to this process.

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