دانلود مقاله ISI انگلیسی شماره 75614
عنوان فارسی مقاله

رابطه بین نوع جهش MECP2 و سلامت و خط سیر استفاده از خدمات در طول زمان در یک جمعیت سندرم رت

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75614 2011 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
The relationship between MECP2 mutation type and health status and service use trajectories over time in a Rett syndrome population
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Research in Autism Spectrum Disorders, Volume 5, Issue 1, January–March 2011, Pages 442–449

کلمات کلیدی
سندرم رت؛ وضعیت سلامت؛ استفاده از خدمات بهداشت و درمان؛ مسیر؛ جهش طولی MECP2؛ رگرسیون چندسطحی
پیش نمایش مقاله
پیش نمایش مقاله رابطه بین نوع جهش MECP2 و سلامت و خط سیر استفاده از خدمات در طول زمان در یک جمعیت سندرم رت

چکیده انگلیسی

This study aimed to investigate the trajectories over time of health status and health service use in Rett syndrome by mutation type. Data were obtained from questionnaires administered over 6 years to 256 participants from the Australian Rett Syndrome Database. Health status (episodes of illness and medication load) and health service use (general practitioner and specialist visits and hospital stays) were summarized into composite scores with principal component analysis. Linear and mixed regression models examined effects of mutation type and other variables on these scores over time. For some mutations (such as p.R255X and p.R168X) health status was poorer at a younger age and improved over time, while for p.R133C it was better at a younger age and deteriorated with time. For those with p.R133C health service use was lowest at a younger age and highest at 25 years. With other mutations, such as p.R255X, p.R270X, p.R294X, C terminal and p.R306C, health service use was higher at a younger age, but dropped off considerably by 25 years of age. Health service use generally declined in parallel with deterioration in health status, although this pattern differed by mutation type, demonstrating important variability in the course of Rett syndrome.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.