دانلود مقاله ISI انگلیسی شماره 75643
عنوان فارسی مقاله

مکانیسم مغز برای مهار پیش پالس در بزرگسالان مبتلا به سندرم تورت: یافته های اولیه

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75643 2013 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 214, Issue 1, 30 October 2013, Pages 33–41

کلمات کلیدی
مهار پیش پالس؛ سندرم تورت؛ راهگاهی حسی؛ مکانیسم های مغزی؛ بزرگسالان
پیش نمایش مقاله
پیش نمایش مقاله مکانیسم مغز برای مهار پیش پالس در بزرگسالان مبتلا به سندرم تورت: یافته های اولیه

چکیده انگلیسی

Prepulse inhibition (PPI) of the startle reflex is disrupted in a number of developmental neuropsychiatric disorders, including Tourette syndrome (TS). This disruption is hypothesized to reflect abnormalities in sensorimotor gating. We applied whole-brain functional magnetic resonance imaging (fMRI) to elucidate the neural correlates of PPI in adult TS subjects using airpuff stimuli to the throat to elicit a tactile startle response. We used a cross-sectional, case-control study design and a blocked-design fMRI paradigm. There were 33 participants: 17 with TS and 16 healthy individuals. As a measure of PPI-related brain activity, we looked for differential cerebral activation to prepulse-plus-pulse stimuli versus activation to pulse-alone stimuli. In healthy subjects, PPI was associated with increased activity in multiple brain regions, of which activation in the left middle frontal gyrus in the healthy controls showed a significant linear correlation with the degree of PPI measured outside of the magnet. Group comparisons identified nine regions where brain activity during PPI differed significantly between TS and healthy subjects. Among the TS subjects, activation in the left caudate was significantly correlated with current tic severity as measured by the total score on the Yale Global Tic Severity Scale. Differential activation of the caudate nucleus associated with current tic severity is consistent with neuropathological data and suggests that portions of cortical–striatal circuits may modulate the severity of tic symptoms in adulthood.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.