دانلود مقاله ISI انگلیسی شماره 75757
عنوان فارسی مقاله

مسیرهای عصبی مختلف به عاطفه منفی در جوانان مبتلا به اختلال دوقطبی اطفال و بهم ریختگی هیجانی خلق و خوی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75757 2011 12 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Different neural pathways to negative affect in youth with pediatric bipolar disorder and severe mood dysregulation
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 45, Issue 10, October 2011, Pages 1283–1294

کلمات کلیدی
اختلال دو قطبی؛ کودکان؛ بهم ریختگی هیجانی خلق و خوی؛ تحریک پذیری؛ نا امیدی؛
پیش نمایش مقاله
پیش نمایش مقاله مسیرهای عصبی مختلف به عاطفه منفی در جوانان مبتلا به اختلال دوقطبی اطفال و بهم ریختگی هیجانی خلق و خوی

چکیده انگلیسی

Questions persist regarding the presentation of bipolar disorder (BD) in youth and the nosological significance of irritability. Of particular interest is whether severe mood dysregulation (SMD), characterized by severe non-episodic irritability, hyper-arousal, and hyper-reactivity to negative emotional stimuli, is a developmental presentation of pediatric BD and, therefore, whether the two conditions are pathophysiologically similar. We administered the affective Posner paradigm, an attentional task with a condition involving blocked goal attainment via rigged feedback. The sample included 60 youth (20 BD, 20 SMD, and 20 controls) ages 8–17. Magnetoencephalography (MEG) examined neuronal activity (4–50 Hz) following negative versus positive feedback. We also examined reaction time (RT), response accuracy, and self-reported affect. Both BD and SMD youth reported being less happy than controls during the rigged condition. Also, SMD youth reported greater arousal following negative feedback than both BD and controls, and they responded to negative feedback with significantly greater activation of the anterior cingulate cortex (ACC) and medial frontal gyrus (MFG) than controls. Compared to SMD and controls, BD youth displayed greater superior frontal gyrus (SFG) activation and decreased insula activation following negative feedback. Data suggest a greater negative affective response to blocked goal attainment in SMD versus BD and control youth. This occurs in tandem with hyperactivation of medial frontal regions in SMD youth, while BD youth show dysfunction in the SFG and insula. Data add to a growing empirical base that differentiates pediatric BD and SMD and begin to elucidate potential neural mechanisms of irritability.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.