دانلود مقاله ISI انگلیسی شماره 75767
عنوان فارسی مقاله

احساس منفی، درد و جنسیت: نقش مواد مخدر درون زا

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75767 2007 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Negative affect, pain and sex: The role of endogenous opioids
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : PAIN, Volume 132, Supplement 1, November 2007, Pages S77–S85

کلمات کلیدی
انتقال های عصبی مواد مخدر؛ نالترکسون؛ استرس روانی؛ دلسردی؛ اثرات جنسیت
پیش نمایش مقاله
پیش نمایش مقاله احساس منفی، درد و جنسیت: نقش مواد مخدر درون زا

چکیده انگلیسی

Opioid neurotransmission modulates pain and negative affect during psychological stress. To determine whether these effects differ between men and women, the opioid receptor antagonist naltrexone or placebo was administered double-blind to 21 men and 22 women before they completed 30 min of difficult mental arithmetic. To heighten negative affect, participants received seven moderately noxious electric shocks during the math task, which were believed to be contingent upon performance. Before and after the math task, participants rated pain intensity and unpleasantness while their left hand was immersed in 2 °C water for up to 4 min. Anxiety, discouragement and anger were also rated before, during and after the math task. Tolerance of cold-induced pain was greater in men, whereas discouragement during the math task was greater in women. Opioid blockade did not influence ratings of negative affect, which increased in line with the intensity and unpleasantness of shock-induced pain. The intensity and unpleasantness of cold-induced pain increased after the math task only in women administered naltrexone. Within the naltrexone condition, pain ratings increased most in the most discouraged subjects. However, this relationship was absent in placebo recipients, implying that the hyperalgesic effect of psychological distress was tempered by opioid release. Greater stress-evoked discouragement in women than men may explain why cold-induced pain increased after the math task only in women administered naltrexone.

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