دانلود مقاله ISI انگلیسی شماره 76048
عنوان فارسی مقاله

رابطه بین نرخ آتروفی منطقه ای و زوال شناختی در اختلال خفیف شناختی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
76048 2012 12 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Relationship between regional atrophy rates and cognitive decline in mild cognitive impairment
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 33, Issue 2, February 2012, Pages 242–253

کلمات کلیدی
زوال شناختی؛ نازک شدن قشر؛ اختلال عملکرد اجرایی؛ نامگذاری؛ تسلط معنایی؛ حافظه کلامی
پیش نمایش مقاله
پیش نمایش مقاله رابطه بین نرخ آتروفی منطقه ای و زوال شناختی در اختلال خفیف شناختی

چکیده انگلیسی

We investigated the relationship between regional atrophy rates and 2-year cognitive decline in a large cohort of patients with mild cognitive impairment (MCI; n = 103) and healthy controls (n = 90). Longitudinal magnetic resonance image (MRI) scans were analyzed using high-throughput image analysis procedures. Atrophy rates were derived by calculating percent cortical volume loss between baseline and 24 month scans. Stepwise regressions were performed to investigate the contribution of atrophy rates to language, memory, and executive functioning decline, controlling for age, gender, baseline performances, and disease progression. In MCI, left temporal lobe atrophy rates were associated with naming decline, whereas bilateral temporal, left frontal, and left anterior cingulate atrophy rates were associated with semantic fluency decline. Left entorhinal atrophy rate was associated with memory decline and bilateral frontal atrophy rates were associated with executive function decline. These data provide evidence that regional atrophy rates in MCI contribute to domain-specific cognitive decline, which appears to be partially independent of disease progression. MRI measures of regional atrophy can provide valuable information for understanding the neural basis of cognitive impairment in MCI.

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