دانلود مقاله ISI انگلیسی شماره 76086
عنوان فارسی مقاله

جسم زرد هورمون به عنوان یک بازیکن کلیدی در زوال شناختی بیماری آلزایمر

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
76086 2015 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
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عنوان انگلیسی
Luteinizing hormone as a key player in the cognitive decline of Alzheimer's disease
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 76, November 2015, Pages 48–56

کلمات کلیدی
هورمون لوتئینی؛ بیماری آلزایمر؛ حافظه؛ پیری - زوال شناختی؛ هورمون آزادکننده گنادوتروپینها
پیش نمایش مقاله
پیش نمایش مقاله جسم زرد هورمون به عنوان یک بازیکن کلیدی در زوال شناختی بیماری آلزایمر

چکیده انگلیسی

Alzheimer's disease is one of the most prevalent and costly neurological diseases in the world. Although decades of research have focused on understanding Alzheimer's disease pathology and progression, there is still a great lack of clinical treatments for those who suffer from it. One of the factors most commonly associated with the onset of Alzheimer's disease is a decrease in levels of gonadal hormones, such as estrogens and androgens. Despite the correlational and experimental data which support the role of these hormones in the etiology of Alzheimer's disease, clinical trials involving their reintroduction through hormone therapy have had varied results and these gonadal hormones often have accompanying health risks. More recently, investigation has turned toward other hormones in the hypothalamic–pituitary–gonadal axis that are disrupted by age-related decreases in gonadal hormones. Specifically, luteinizing hormone, which is increased with age in both men and women (in response to removal of negative feedback), has surfaced as a potentially powerful player in the risk and onset of Alzheimer's disease. Mounting evidence in basic research and epidemiological studies supports the role of elevated luteinizing hormone in exacerbating age-related cognitive decline in both males and females. This review summarizes the recent developments involving luteinizing hormone in increasing the cognitive deficits and molecular pathology characteristic of Alzheimer's disease.

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