دانلود مقاله ISI انگلیسی شماره 76398
عنوان فارسی مقاله

رفتار غذایی، رشد پیش از تولد و بعد از تولد در سندرم آنجلمن

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
76398 2014 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Eating behavior, prenatal and postnatal growth in Angelman syndrome
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Research in Developmental Disabilities, Volume 35, Issue 11, November 2014, Pages 2681–2690

کلمات کلیدی
سندرم آنجلمن؛ رفتار غذایی؛ ژنوتیپ فنوتیپ؛ اندازه دور سر؛ چاقی؛ رشد پیش از تولد؛ رشد بعد از تولد
پیش نمایش مقاله
پیش نمایش مقاله رفتار غذایی، رشد پیش از تولد و بعد از تولد در سندرم آنجلمن

چکیده انگلیسی

The objectives of the present study were to investigate eating behavior and growth parameters in Angelman syndrome. We included 39 patients with Angelman syndrome. Twelve cases had a larger Class I deletion, eighteen had a smaller Class II deletion, whereas paternal uniparental disomy (pUPD) or a verified UBE3A mutation were present in five and four cases, respectively. Eating behavior was assessed by a questionnaire. Anthropometric measures were obtained from medical records and compared to Danish reference data. Children with pUPD had significantly larger birth weight and birth length than children carrying a deletion or a UBE3A mutation. We found no difference in birth weight or length in children with Class I or Class II deletions. When maternal birth weight and/or birth weight of siblings were taken into consideration, children with Class I deletion had a lower weight at birth than expected, and the weight continued to be reduced during the investigated initial five years of life. In contrast, children with pUPD showed hyperphagic behavior and their weight increased significantly after the age of two years. Accordingly, their body mass index was significantly increased as compared to children with a deletion. At birth, one child showed microcephaly. At five years of age, microcephaly was observed in half of the deletion cases, but in none of the cases with a UBE3A mutation or pUPD. The apparently normal cranial growth in the UBE3A and pUPD patients should however be regarded as the result of a generally increased growth. Eating behavior, pre- and postnatal growth in children with Angelman syndrome depends on genotype.

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