دانلود مقاله ISI انگلیسی شماره 76630
عنوان فارسی مقاله

اعصاب و غدد افتراقی و پاسخ های ایمنی به استرس روانی- اجتماعی حاد در زنان مبتلا به به اختلال دو قطبی نوع 1

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
76630 2013 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Differential neuroendocrine and immune responses to acute psychosocial stress in women with type 1 bipolar disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Brain, Behavior, and Immunity, Volume 34, November 2013, Pages 47–55

کلمات کلیدی
اختلال دو قطبی؛ استرس روانی- اجتماعی؛ التهاب؛ زیر مجموعه های لنفوسیت
پیش نمایش مقاله
پیش نمایش مقاله اعصاب و غدد افتراقی و پاسخ های ایمنی به استرس روانی- اجتماعی حاد در زنان مبتلا به به اختلال دو قطبی نوع 1

چکیده انگلیسی

Bipolar disorder (BD) has been associated with immune imbalance, including lymphocyte activation and increased pro-inflammatory cytokines. Immune activation is part of stress response, and psychosocial stress has been implicated in the pathogenesis of psychiatric disorders. Here, we investigated the neuroendocrine and immune responses to acute psychosocial stress challenge in BD. Thirteen euthymic participants with type 1 BD and 15 healthy controls underwent the Trier Social Stress Test protocol (TSST). Blood samples were collected before and after TSST. Lymphocytes were isolated and stimulated in vitro to assess lymphocyte activation profile, lymphocyte sensitivity to dexamethasone, mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling by flow cytometry. Heart rate and salivary cortisol levels were monitored across the task. BD participants exhibited blunted stress responses as shown by reduced heart rate and salivary cortisol levels in comparison to healthy controls. BD was also associated with reduction in the percentage of regulatory T cells, but with expansion of activated T cells. When compared to controls, patients showed increased lymphocyte MAPK p-ERK and p-NF-κB signaling after the stress challenge, but exhibited a relative lymphocyte resistance to dexamethasone. In conclusion, stress-related neuroendocrine responses are blunted, associated with increased immune activation and lower sensitivity to glucocorticoids in BD. An inability in reducing NF-κB and MAPK signaling following TSST could be underlying the immune imbalance observed in BD.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.