دانلود مقاله ISI انگلیسی شماره 76633
عنوان فارسی مقاله

مواجهه بارداری با استرس روانی- اجتماعی مادر و مقررات محور HPA در بزرگسالان جوان

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
76633 2009 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 55, Issue 2, February 2009, Pages 292–298

کلمات کلیدی
استرس در دوران بارداری؛ استرس روانی- اجتماعی؛ محور (HPA) هیپوتالاموس-هیپوفیز-آدرنال ؛ تست استرس ازماینده اجتماعی
پیش نمایش مقاله
پیش نمایش مقاله مواجهه بارداری با استرس روانی- اجتماعی مادر و مقررات محور HPA در بزرگسالان جوان

چکیده انگلیسی

Epidemiological studies have reported associations between measures of size and weight at birth and disease risk in later life. Alteration in the regulation of the hypothalamic–pituitary–adrenal (HPA) axis in response to prenatal stress has been proposed as one underlying mechanism. The present study investigated in humans the association of prenatal psychosocial stress exposure with subsequent HPA axis regulation in adult life, with a focus on measures of response to challenge and feedback sensitivity. Healthy young adults whose mothers experienced severe stress during their pregnancy in form of major negative life events (e.g. death of someone close; prenatal stress (PS) group, n = 31) and an age-matched comparison group (CG, n = 30) underwent the Trier Social Stress Test (TSST) and a 1 μg ACTH1–24 stimulation test. In addition, a diurnal cortisol profile was assessed. ACTH concentrations following a standardized behavioural challenge paradigm (TSST) were marginally significantly higher in PS subjects than in CG subjects (p = .06). Pre-TSST adrenocortical (cortisol) levels were lower (p = .007), whereas the increase in cortisol in response to the TSST was higher (p = .03) in PS subjects compared to CG subjects. Cortisol concentrations following a pharmacological stimulation test simulating pituitary activity (ACTH1–24 test) were significantly lower in PS than in CG subjects (p = .006). No differences emerged between the two groups in basal diurnal cortisol levels. This study provides first evidence in humans of an association between prenatal psychosocial stress exposure and subsequent alterations in the regulation of the HPA axis.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.