دانلود مقاله ISI انگلیسی شماره 76716
عنوان فارسی مقاله

وازوپرسین آرژنین و ترشح ﺁدرﻧﻮﮐﻮرﺗﻴﮑﻮﺗﺮوﭘﻴﮏ در پاسخ به استرس روانی- اجتماعی توسط اتانول در پسر پدران وابسته به الکل ضعیف است

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
76716 2004 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 38, Issue 4, July–August 2004, Pages 385–393

کلمات کلیدی
استرس روانی- اجتماعی؛ اعتیاد به الکل؛ خطر ژنتیکی؛ اتانول؛ سیستم HPA
پیش نمایش مقاله
پیش نمایش مقاله وازوپرسین آرژنین و ترشح ﺁدرﻧﻮﮐﻮرﺗﻴﮑﻮﺗﺮوﭘﻴﮏ در پاسخ به استرس روانی- اجتماعی توسط اتانول در پسر پدران وابسته به الکل ضعیف است

چکیده انگلیسی

Familial risk and environmental stress promote the development of alcohol dependence. We investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders. Twenty-four high-risk subjects with a paternal history of alcoholism (PHA) and 16 family history negative (FHN) controls were evaluated. Psychosocial stress was induced by having subjects deliver a 5-min speech and mental arithmetics in front of an audience on separate days, after drinking either placebo or ethanol (0.6 g/kg) in a randomized sequence. Adrenocorticotropin (ACTH) was measured in 10 plasma samples covering up to 75 min after the stress test. Plasma arginine vasopressin (AVP) was determined before the stressor, at the time of maximum ACTH secretion, and at 75 min after stress onset. The stress test induced a phasic increase in ACTH secretion. At the time of maximum ACTH, AVP was significantly increased in relation to baseline. Compared to placebo, alcohol administration significantly attenuated maximum ACTH concentration in PHA but not FHN subjects, and decreased AVP measured in the same samples in PHA but not FHN subjects. We conclude that activation of the hypothalamic–pituitary–adrenal system by psychosocial stress is accompanied by an increase in peripheral plasma AVP levels. Secretion of both ACTH and AVP suggest that alcohol attenuates the stress response selectively in PHA but not FHN subjects. This might imply some short-term positive alcohol effect in sons of alcoholics, but also constitute a mechanism by which their risk to develop alcohol use disorders is increased.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.