عدم تعادل پیشرو در تعامل بین سیستم های حافظه فضایی و رویه ای در مدل ماوس ماوس R6 / 2 از بیماری هانتینگتون
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|76757||2009||12 صفحه PDF||سفارش دهید||8983 کلمه|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Neurobiology of Learning and Memory, Volume 92, Issue 3, October 2009, Pages 417–428
When Huntington’s disease (HD) patients are tested on cognitive tasks that involve both striatal and hippocampal memory systems, a decline in their striatal function is compensated for by an increase in hippocampal activity that allows these patients to achieve an optimal performance [Voermans, N. C., Petersson, K. M., Daudley, L., Weber, B., van Spaendonck, K. P., Kremer, H. P. H., et al. (2004). Interaction between the human hippocampus and the caudate nucleus during route recognition. Neuron, 43, 427–435]. Our recent study suggests that there is also an imbalance between hippocampal and striatal memory systems in R6/2 mice, a widely used animal model of HD [Ciamei, A., & Morton, A. J. (2008). Rigidity in social and emotional memory in the R6/2 mouse model of Huntington’s disease. Neurobiology of Learning and Memory, 89, 533–544]. However, interactions between multiple memory systems have never been studied directly in HD mice. Here, we used a water maze task to examine striatal and hippocampal systems directly. R6/2 mice were trained to swim from a fixed starting point to a cued platform. During the probe test, the apparatus was rotated by 180°, and mice had to choose between a hidden platform located where the cued platform had been during training (place learning), and a cued platform that was now located in the opposite quadrant (cue learning). Probe trial results showed that in 8 week old R6/2 mice the escape response was driven mainly by a cue-based strategy (striatal), whereas by 12 weeks of age, a higher proportion of mice adopted a place-based strategy (hippocampal) to escape from the maze. We conclude that following striatal decline in R6/2 mice between 8 and 12 weeks of age, hippocampal functions emerge to drive the escape response of R6/2 mice.