دانلود مقاله ISI انگلیسی شماره 76796
عنوان فارسی مقاله

مزمن شدن افسردگی و پاسخ کورتیزول به استرس روانی- اجتماعی در نوجوانان: مطالعه آزمایشی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
76796 2013 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Chronicity of depressive problems and the cortisol response to psychosocial stress in adolescents: The TRAILS study
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 38, Issue 5, May 2013, Pages 659–666

کلمات کلیدی
واکنش استرس؛ محور HPA؛ نوجوانان؛ افسردگی؛ اثرات منحنی؛
پیش نمایش مقاله
پیش نمایش مقاله مزمن شدن افسردگی و پاسخ کورتیزول به استرس روانی- اجتماعی در نوجوانان: مطالعه آزمایشی

چکیده انگلیسی

Clinical and epidemiological studies, further supported by meta-analytic studies, indicate a possible association between chronicity (i.e., persistence or recurrence) of depression and hypothalamic–pituitary–adrenal (HPA) axis responsiveness to psychosocial stress. In the present study, we examined whether and how chronicity of depressive problems predicts cortisol responses to a standardized social stress test in adolescents. Data were collected in a high-risk focus sample (n = 351) of the Tracking Adolescents’ Individual Lives Survey (TRAILS) cohort, a large prospective population study with bi- to triennial measurements. Depressive problems were assessed around age 11, 13.5, and 16. Cortisol levels were measured in saliva, sampled before, during, and after the Groningen Social Stress Test (GSST), to determine the cortisol response to psychosocial stress. The area under the curve with respect to the increase (AUCi) (i.e., change from baseline) of the cortisol response was used as a measure of HPA axis response. By means of linear regression analysis and repeated-measures analysis of variance, it was examined whether chronicity of depressive problems predicted the cortisol response to the GSST around the age of 16. Chronicity of depressive problems was significantly associated with cortisol stress responses. The relationship was curvilinear, with recent-onset depressive problems predicting an increased cortisol response, and more chronic depressive problems a blunted response. The results of this study suggest that depressive problems initially increase cortisol responses to stress, but that this pattern reverses when depressive problems persist over prolonged periods of time.

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