دانلود مقاله ISI انگلیسی شماره 77050
عنوان فارسی مقاله

شدت دمانس و لوی بادی ریتم شبانه روزی در بیماری آلزایمر را تحت تاثیر قرار می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77050 2004 11 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 25, Issue 6, July 2004, Pages 771–781

کلمات کلیدی
چرخه استراحت، فعالیت، ریتم دمای هسته بدن - انسان؛ خواب؛ بیماری پارکینسون؛ زوال عقل؛ بیماری آلزایمر؛ ریتم شبانه روزی
پیش نمایش مقاله
پیش نمایش مقاله شدت دمانس و لوی بادی ریتم شبانه روزی در بیماری آلزایمر را تحت تاثیر قرار می دهد

چکیده انگلیسی

Sleep disturbance is a symptom shared by all neurodegenerative, dementing illnesses, such as Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), and its presence frequently precipitates decisions to seek institutional care for patients. Although the sleep disturbances of AD and DLB are qualitatively similar, they appear to be more prominent in patients with DLB. Disturbance of the circadian rhythm has been noted and is a potential factor underlying the nocturnal sleep fragmentation and daytime sleepiness observed in these patients. We studied the circadian variation of core-body temperature and motor activity in a total of 32 institutionalized patients with probable AD by NINCDS-ADRDA criteria, 9 of whom also met pathologic criteria for DLB. Eight, healthy, elderly male controls were studied on a clinical research unit designed to simulate the hospital environment where the dementia patients were studied. Circadian variables generally had greater deviations from normal associated with increasing AD pathology, as measured by postmortem-determined Braak stage, supporting the hypothesis that central changes mediate circadian disturbances in AD and DLB. Patients with a postmortem diagnosis of DLB manifested greater disturbances of locomotor activity circadian rhythms than patients with AD, possibly reflecting the greater sleep disturbances seen in this population, but the differences from normal in the circadian rhythms of the AD and DLB patients were qualitatively similar.

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