دانلود مقاله ISI انگلیسی شماره 77051
عنوان فارسی مقاله

اثر گیرنده های آدرنرژیک CA1 α2 در کسری حافظه ناشی از محرومیت از خواب کل و برگشت از ریتم شبانه روزی در مدل موش

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77051 2016 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
The effect of CA1 α2 adrenergic receptors on memory retention deficit induced by total sleep deprivation and the reversal of circadian rhythm in a rat model
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 133, September 2016, Pages 53–60

کلمات کلیدی
کمبود خواب - واژگونی ریتم شبانه روزی؛ هیپوکامپ؛ یوهیمبین؛ کلونیدین
پیش نمایش مقاله
پیش نمایش مقاله اثر گیرنده های آدرنرژیک CA1 α2 در کسری حافظه ناشی از محرومیت از خواب کل و برگشت از ریتم شبانه روزی در مدل موش

چکیده انگلیسی

The α2 adrenergic receptors which abundantly express in the CA1 region of the hippocampus play an important role in the regulation of sleep and memory retention processes. Based on the available evidence, the aim of our study was to investigate consequences of the activation and deactivation of CA1 α2 adrenergic receptors (by clonidine and yohimbine, respectively) on the impairment of memory retention induced by total sleep deprivation (TSD) and the reversal of circadian rhythm (RCR) in a rat model. To this end, the water box apparatus and passive avoidance task were in turn used to induce sleep deprivation and assess memory retention. Our findings suggested that TSD (for 24 and 36, but not 12 h) and RCR (12 h/day for 3 consecutive days) impair memory function. The post-training intra-CA1 administration of yohimbine (α2 adrenergic receptor antagonist) on its own, at the dose of 0.1 μg/rat, decreased the step-through latency and locomotor activity in the TSD- sham treated but not undisturbed sleep rats. Unlike yohimbine, clonidine (α2 adrenergic receptor agonist), in all applied doses (0.001, 0.01 and 0.1 μg/rat), failed to induce such an effect. While the subthreshold dose of yohimbine (0.001 μg/rat) abrogated the impairment of memory retention induced by the 24-h TSD, it could potentiate the impairment of memory retention induced by 36-h TSD, suggesting the modulatory effect of yohimbine. Moreover, the subthreshold dose of clonidine (0.1 μg/rat) restored the memory retention deficit in TSD rats (24 and 36 h). On the other hand, the subthreshold dose of clonidine (0.1 μg/rat), but not yohimbine (0.001 μg/rat) restored the memory retention deficit in RCR rats. Such interventions however did not alter the locomotor activity. The above observations proposed that CA1 α2 adrenergic receptors play a potential role in memory retention deficits induced by TSD and RCR.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.