دانلود مقاله ISI انگلیسی شماره 77067
عنوان فارسی مقاله

زمینه ژنتیکی کاهش وابسته به سن در پاسخ شبکیه غیر بصری و ریتم شبانه روزی، و خواب را را تحت تاثیر قرار می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77067 2015 14 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Genetic background influences age-related decline in visual and nonvisual retinal responses, circadian rhythms, and sleep ☆
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 36, Issue 1, January 2015, Pages 380–393

کلمات کلیدی
پیری - شبانه روزی؛ خواب؛ ورودی نور؛ فشار ماوس
پیش نمایش مقاله
پیش نمایش مقاله زمینه ژنتیکی کاهش وابسته به سن در پاسخ شبکیه غیر بصری و ریتم شبانه روزی، و خواب را را تحت تاثیر قرار می دهد

چکیده انگلیسی

The circadian system is entrained to the environmental light/dark cycle via retinal photoreceptors and regulates numerous aspects of physiology and behavior, including sleep. These processes are all key factors in healthy aging showing a gradual decline with age. Despite their importance, the exact mechanisms underlying this decline are yet to be fully understood. One of the most effective tools we have to understand the genetic factors underlying these processes are genetically inbred mouse strains. The most commonly used reference mouse strain is C57BL/6J, but recently, resources such as the International Knockout Mouse Consortium have started producing large numbers of mouse mutant lines on a pure genetic background, C57BL/6N. Considering the substantial genetic diversity between mouse strains we expect there to be phenotypic differences, including differential effects of aging, in these and other strains. Such differences need to be characterized not only to establish how different mouse strains may model the aging process but also to understand how genetic background might modify age-related phenotypes. To ascertain the effects of aging on sleep/wake behavior, circadian rhythms, and light input and whether these effects are mouse strain-dependent, we have screened C57BL/6J, C57BL/6N, C3H-HeH, and C3H-Pde6b+ mouse strains at 5 ages throughout their life span. Our data show that sleep, circadian, and light input parameters are all disrupted by the aging process. Moreover, we have cataloged a number of strain-specific aging effects, including the rate of cataract development, decline in the pupillary light response, and changes in sleep fragmentation and the proportion of time spent asleep.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.