دانلود مقاله ISI انگلیسی شماره 77096
عنوان فارسی مقاله

مطالعه ترکیبی از عصب روانشناختی و تصویربرداری حافظه های توپوگرافی و غیر کلامی در زوال عقل معنایی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77096 2003 12 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
A combined neuropsychological and neuroimaging study of topographical and non-verbal memory in semantic dementia
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 41, Issue 9, 2003, Pages 1148–1159

کلمات کلیدی
زوال عقل معنایی؛ حافظه توپوگرافی؛ تصویربرداری عصبی عملکردی؛ حافظه بصری
پیش نمایش مقاله
پیش نمایش مقاله مطالعه ترکیبی از عصب روانشناختی و تصویربرداری حافظه های توپوگرافی و غیر کلامی در زوال عقل معنایی

چکیده انگلیسی

A combined neuropsychological and neuroimaging investigation was carried out on a patient (O.I.) with semantic dementia who had asymmetrical temporal lobe atrophy, greater on the left. His performance on tests of verbal memory was gravely impaired. Similarly, his visual memory as indexed by recognition of unfamiliar faces was impaired. By contrast, his recognition memory for topographical memoranda (e.g. buildings, landscapes) and ability to find his way around was preserved. In order to identify the neural substrates supporting the preserved recognition of static topographical memoranda, O.I. was scanned using positron emission tomography (PET) during the encoding and recognition of building and landscape stimuli. In common with control subjects, during encoding O.I. activated parahippocampal cortex bilaterally, along with bilateral temporo-parietal, retrosplenial and left frontal cortices. During recognition, both patient and controls activated right parahippocampal, right superior parietal and right frontal cortices. Notably, control subjects, but not O.I., also activated at encoding the precuneus and at recognition the retrosplenial cortex. This allows the conclusion that these two areas while involved may not be necessary for topographical memory. Interestingly, the patient also activated regions that were not evident in control subjects both during encoding and recognition. These additional areas of activation may be necessary in a compensatory role. Overall, these data represent the first reported assessment of the functional integrity of degenerating brain tissue and its contribution to preserved topographical memory. The combination of the neuropsychological and neuroimaging approaches may provide insights into the functional-anatomy of memory while having clinical utility for the assessment of residual brain tissue.

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