دانلود مقاله ISI انگلیسی شماره 77131
عنوان فارسی مقاله

اثرات جنسیت و پیری طبیعی بر فعال شدن منطقه ای مغز در طول عملکرد حافظه کلامی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77131 2010 13 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Effects of sex and normal aging on regional brain activation during verbal memory performance
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 31, Issue 5, May 2010, Pages 826–838

کلمات کلیدی
پیری - بزرگسالان سالم؛ تفاوت جنسیتی؛ سینگولیت؛ قشر جلوی مغز
پیش نمایش مقاله
پیش نمایش مقاله اثرات جنسیت و پیری طبیعی بر فعال شدن منطقه ای مغز در طول عملکرد حافظه کلامی

چکیده انگلیسی

This study examined the main and interactive effects of age and sex on relative glucose metabolic rate (rGMR) within gray matter of 39 cortical Brodmann areas (BAs) and the cingulate gyrus using 18FDG-PET during a verbal memory task in 70 healthy normal adults, aged 20–87 years. Women showed significantly greater age-related rGMR decline in left cingulate gyrus than men (BAs 25, 24, 23, 31, 29). Both groups showed a decline in the anterior cingulate—a neuroanatomical structure that mediates effective cognitive-emotional interactions (BAs 32, 24, 25), while the other frontal regions did not show substantial decline. No sex differences in rGMR were identified within temporal, parietal and occipital lobes. Sex differences were observed for rGMR within subcomponents of the cingulate gyrus with men higher in BA25 and BA29, but lower in BA24 and BA 23 compared to women. For men, better memory performance was associated with greater rGMR in BA24, whereas in women better performance was associated with orbitofrontal-BA12. These results suggest that both age-related metabolic decline and sex differences within frontal regions are more marked in medial frontal and cingulate areas, consistent with some age-related patterns of affective and cognitive change.

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