دانلود مقاله ISI انگلیسی شماره 77145
عنوان فارسی مقاله

حجم آمیگدال-هیپوکامپ و حافظه کلامی در بستگان درجه اول بیماران اسکیزوفرنیک

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77145 2001 11 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Amygdala–hippocampal volume and verbal memory in first-degree relatives of schizophrenic patients
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 107, Issue 2, 25 August 2001, Pages 75–85

کلمات کلیدی
هیپوکامپ؛ آزمون عصب روان شناختی؛ اسکیزوفرنی؛ استعداد ژنتیکی برای بیماری
پیش نمایش مقاله
پیش نمایش مقاله حجم آمیگدال-هیپوکامپ و حافظه کلامی در بستگان درجه اول بیماران اسکیزوفرنیک

چکیده انگلیسی

Verbal memory deficits have been related to reduced volume of medial temporal structures in several neurological and psychiatric populations, including schizophrenic patients. Impairments in verbal memory have been proposed to be a marker of risk for schizophrenia. Recently, relatives of schizophrenic patients have been reported to have reduced volume of the amygdala–hippocampal complex. In this study, we evaluate the possibility that amygdala–hippocampal volume reductions may constitute one neural substrate of verbal memory deficits in first-degree relatives. Subjects were 20 healthy first-degree relatives of schizophrenic patients and 14 demographically similar controls. Verbal memory was assessed with the Logical Memory Test. Subjects were scanned with high-resolution MRI and the images were transformed into Talairach space. Volumes of interest were amygdala–anterior hippocampus and posterior hippocampus. Relatives of schizophrenic patients had intact immediate verbal memory but significantly poorer delayed verbal memory than controls. Relatives also had significantly reduced amygdala–anterior hippocampus volumes. Across all subjects, delayed verbal memory was significantly correlated with amygdala–anterior hippocampus volume. The magnitude of the correlation did not differ between the groups. These data provide an empirical link between memory performance and volumetric abnormalities in the amygdala–hippocampal complex in the relatives of schizophrenic patients.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.