دانلود مقاله ISI انگلیسی شماره 77164
عنوان فارسی مقاله

تضعیف ایمی پرامین سیگنالینگ عصبی التهابی و اجتناب اجتماعی ناشی از استرس معکوس

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77164 2015 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Brain, Behavior, and Immunity, Volume 46, May 2015, Pages 212–220

کلمات کلیدی
استرس روانی؛ شکست های اجتماعی؛ ایمی پرامین - اجتناب اجتماعی؛ میکروگلیا
پیش نمایش مقاله
پیش نمایش مقاله تضعیف ایمی پرامین سیگنالینگ عصبی التهابی و اجتناب اجتماعی ناشی از استرس معکوس

چکیده انگلیسی

Psychosocial stress is associated with altered immunity, anxiety and depression. Previously we showed that repeated social defeat (RSD) promoted microglia activation and social avoidance behavior that persisted for 24 days after cessation of RSD. The aim of the present study was to determine if imipramine (a tricyclic antidepressant) would reverse RSD-induced social avoidance and ameliorate neuroinflammatory responses. To test this, C57BL/6 mice were divided into treatment groups. One group from RSD and controls received daily injections of imipramine for 24 days, following 6 cycles of RSD. Two other groups were treated with saline. RSD mice spent significantly less time in the interaction zone when an aggressor was present in the cage. Administration of imipramine reversed social avoidance behavior, significantly increasing the interaction time, so that it was similar to that of control mice. Moreover, 24 days of imipramine treatment in RSD mice significantly decreased stress-induced mRNA levels for IL-6 in brain microglia. Following ex vivo LPS stimulation, microglia from mice exposed to RSD, had higher mRNA expression of IL-6, TNF-α, and IL-1β, and this was reversed by imipramine treatment. In a second experiment, imipramine was added to drinking water confirming the reversal of social avoidant behavior and decrease in mRNA expression of IL-6 in microglia. These data suggest that the antidepressant imipramine may exert its effect, in part, by down-regulating microglial activation.

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