دانلود مقاله ISI انگلیسی شماره 77196
عنوان فارسی مقاله

سهم گیرنده N- متیل-D-آسپارتات به توجه و حافظه فضایی اپیزودیک در طول پیری

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77196 2015 11 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Contribution of N-methyl-D-aspartate receptors to attention and episodic spatial memory during senescence
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 125, November 2015, Pages 36–46

کلمات کلیدی
پیری - هیپوکامپ؛ قشر جلوی مغز؛ گیرنده NMDA؛ حافظه اپیزودیک؛ توجه
پیش نمایش مقاله
پیش نمایش مقاله سهم گیرنده N- متیل-D-آسپارتات به توجه و حافظه فضایی اپیزودیک در طول پیری

چکیده انگلیسی

A decrease in N-methyl-D-aspartate receptor (NMDAR) function is associated with age-related cognitive impairments. However, NMDAR antagonists are prescribed for cognitive decline associated with age-related neurodegenerative disease, raising questions as to the role of NMDAR activity in cognitive function during aging. The current studies examined effects of NMDAR blockade on cognitive task that are sensitive to aging. Young and middle-age rats were trained on the five-choice serial reaction time task (5-CSRTT) and challenged with MK-801 (0.025, 0.05, and 0.1 mg/kg or vehicle). Attention deficits were apparent in middle-age and performance of young and middle-age rats was enhanced for low doses of MK-801 (0.025 and 0.05). The beneficial effects on attention were reversed by the highest dose of MK-801. Older animals exhibited a delay-dependent impairment of episodic spatial memory examined on a delayed-matching to place water maze task. Similarly, a low dose of MK-801 (0.05 mg/kg) impaired performance with increasing delay and aged animals were more susceptible to disruption by NMDAR blockade. Despite MK-801 impairment of episodic spatial memory, MK-801 had minimal effects on spatial reference memory. Our results confirm that NMDARs contribute to rapidly acquired and flexible spatial memory and support the idea that a decline in NMDAR function contributes to the age-related impairments in cognition.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.