دانلود مقاله ISI انگلیسی شماره 77200
عنوان فارسی مقاله

گنادوتروپین جفتی انسان (یک همولوگ هورمون جسم زرد) حافظه فضایی را کاهش می دهد و سطح آمیلوئید β مغز در موش های ماده را افزایش می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77200 2008 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-β levels in female rats
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 54, Issue 1, June 2008, Pages 143–152

کلمات کلیدی
حافظه؛ حافظه فضایی؛ هورمون لوتئینی؛ آمیلوئید β؛ استرادیول - هیپوکامپ؛ آلزایمر
پیش نمایش مقاله
پیش نمایش مقاله گنادوتروپین جفتی انسان (یک همولوگ هورمون جسم زرد) حافظه فضایی را کاهش می دهد و سطح آمیلوئید β مغز در موش های ماده را افزایش می دهد

چکیده انگلیسی

Numerous studies have suggested that estradiol (E) improves spatial memory as female rats with E perform better than those without E. However there is an inverse relationship between E and luteinizing hormone (LH) levels and LH could play a role. We examined whether treatment with the LH homologue human chorionic gonadotropin (hCG), would impair spatial memory of adult E-treated female rats. In the object location memory task, ovariectomized (ovxed) rats treated with E and either a single high dose (400 IU/kg) or a lower repeated dose of hCG (75 IU/kg hourly for 8 h) showed spatial memory disruption compared to ovxed rats treated with estradiol alone. Impairment was attributed to memory disruption as performance improved with shortened delay between task exposure and testing. Tests on another spatial memory task, the Barnes maze, confirmed that hCG (400 IU/kg) can impair memory: although E + veh treated animals made significantly fewer hole errors across time, E + hCG-treated did not. In humans, high LH levels have been correlated with Alzheimer's disease (AD). Because brain amyloid-beta (Aβ) species have been implicated as a toxic factor thought to cause memory loss in AD, we analyzed whether hCG-treated animals had increased Aβ levels. Levels of Aβ from whole brains or hippocampi were assessed by Western blot. hCG treatment to E-implanted females significantly increased soluble Aβ40 and Aβ42 levels. These results indicate that high levels of LH/hCG can impair spatial memory, and an increase in brain Aβ species may account for the memory impairment in hCG-treated rats.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.