دانلود مقاله ISI انگلیسی شماره 77209
عنوان فارسی مقاله

هسته تالاموس قدامی و نه بین لایه ای از حافظه فضایی جامع پشتیبانی می کند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77209 2008 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
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عنوان انگلیسی
Anterior but not intralaminar thalamic nuclei support allocentric spatial memory
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 90, Issue 1, July 2008, Pages 71–80

کلمات کلیدی
هسته تالاموس قدامی؛ هسته تالاموس بین لایه ای؛ حافظه فضایی جامع؛ حافظه فضایی خود محور - ماز آب؛ موش
پیش نمایش مقاله
پیش نمایش مقاله هسته تالاموس قدامی و نه بین لایه ای از حافظه فضایی جامع پشتیبانی می کند

چکیده انگلیسی

Medial thalamic damage is a common cause of severe memory disruption in humans. Both the anterior thalamic nuclei (ATN) and the intralaminar thalamic nuclei (ILN) have been suggested as primary sites of diencephalic injury underlying learning and memory deficits, but their respective roles have yet to be resolved. The present study explicitly compared two spatial memory tasks in male PVGc hooded rats with selective neurotoxic lesions to either (1) the ATN or (2) the rostral ILN (and adjacent lateral mediodorsal thalamic nuclei; ILN/LT lesions). As predicted, the ATN group, but not the ILN/LT group, exhibited clear deficits in the Morris water maze task for the initial acquisition of a fixed hidden platform and its reversal to a new position. The second task examined acquisition of egocentric spatial reference memory for a left or right body turn, using any three arms in an 8-arm water maze on any given trial; contrary to predictions, both lesion groups performed as well as the Sham group. The lack of deficits in ILN/LT rats on this second task contrasted with previous findings reporting a detrimental effect of ILN/LT lesions on egocentric working memory. The clear dissociation between the influence of ATN and ILN/LT lesions with respect to allocentric spatial reference memory in the Morris maze emphasizes that caution is required when interpreting the effects of non-ATN thalamic lesions on spatial memory when the lesions encroach substantial areas of the adjacent ATN region.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.