اثرات دی گالاکتوز روی ظهور هیپوکامپ گیرنده محیطی نوع بنزودیازپین و اجرای حافظه فضایی در موش
|کد مقاله||سال انتشار||مقاله انگلیسی||ترجمه فارسی||تعداد کلمات|
|77224||2006||7 صفحه PDF||سفارش دهید||3578 کلمه|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Psychoneuroendocrinology, Volume 31, Issue 7, August 2006, Pages 805–811
The changes in spatial memory performances and the binding of hippocampal peripheral-type benzodiazepine receptor (PBR) induced by d-galactose (d-gal) were investigated in rats. The animals were randomly divided into two groups: saline-treated group and d-gal-induced aging group. All rats received 56 days of injection followed by 5 days of behavioral tests. The d-gal-induced aging rats presented significant impairment in water maze performance, compared with that in the saline-treated rats. A significant decrease in [3H]PK11195 binding in the synaptosomes from hippocampus in the d-gal-induced aging rats was observed, compared to that in the saline-treated rats. Meanwhile, the Scatchard analysis revealed that there was a decrease in Bmax, with no significant change in KD. Further analysis demonstrated that water maze performance was closely related to the PK11195 binding in all rats. These results suggest that d-gal decreased the density of PBR in hippocampal synaptosomes, which may be attributable to the progressive pathogenesis of aging in rats.