دانلود مقاله ISI انگلیسی شماره 77225
عنوان فارسی مقاله

اختلالات حافظه فضایی و تسهیل هماهنگی حرکتی در نوع پروتئین کیناز اختلال II موش وابسته به cGMP

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77225 2013 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 99, January 2013, Pages 32–37

کلمات کلیدی
حافظه؛ کیناز؛ یادگیری؛ گیرنده های AMPA
پیش نمایش مقاله
پیش نمایش مقاله اختلالات حافظه فضایی و تسهیل هماهنگی حرکتی در نوع پروتئین کیناز اختلال  II موش وابسته به cGMP

چکیده انگلیسی

Activity-dependent trafficking of AMPA receptors to synapses regulates synaptic strength. Activation of the NMDA receptor induces several second messenger pathways that contribute to receptor trafficking-dependent plasticity, including the NO pathway, which elevates cGMP. In turn, cGMP activates the cGMP-dependent protein kinase type II (cGKII), which phosphorylates the AMPA receptor subunit GluA1 at serine 845, a critical step facilitating synaptic delivery in the mechanism of activity-dependent synaptic potentiation. Since cGKII is expressed in the striatum, amygdala, cerebral cortex, and hippocampus, it has been proposed that mice lacking cGKII may present phenotypic differences compared to their wild-type littermates in emotion-dependent tasks, learning and memory, and drug reward salience. Previous studies have shown that cGKII KO mice ingest higher amounts of ethanol as well as exhibit elevated anxiety levels compared to wild-type (WT) littermates. Here, we show that cGKII KO mice are significantly deficient in spatial learning while exhibiting facilitated motor coordination, demonstrating a clear dependence of memory-based tasks on cGKII. We also show diminished GluA1 phosphorylation in the postsynaptic density (PSD) of cGKII KO prefrontal cortex while in hippocampal PSD fractions, phosphorylation was not significantly altered. These data suggest that the role of cGKII may be more robust in particular brain regions, thereby impacting complex behaviors dependent on these regions differently.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.