دانلود مقاله ISI انگلیسی شماره 77234
عنوان فارسی مقاله

انواع مختلف غنی سازی زیست محیطی اثرات مغایر با شرایط اعتبار در سطح حافظه و سیناپتوفیزین فضایی در موش های ماده

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77234 2005 11 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 83, Issue 3, May 2005, Pages 206–216

کلمات کلیدی
ماز شعاعی؛ حافظه کاری؛ حافظه مرجع؛ موش؛ ورزش؛ یادگیری مهارت های حرکتی
پیش نمایش مقاله
پیش نمایش مقاله انواع مختلف غنی سازی زیست محیطی اثرات مغایر با شرایط اعتبار در سطح حافظه و سیناپتوفیزین فضایی در موش های ماده

چکیده انگلیسی

Environmental enrichment paradigms that incorporate cognitive stimulation, exercise, and motor learning benefit memory and synaptic plasticity across the rodent lifespan. However, the contribution each individual element of the enriched environment makes to enhancing memory and synaptic plasticity has yet to be delineated. Therefore, the current study tested the effects of three of these elements on memory and synaptic protein levels. Young female C57BL/6 mice were given 3 h of daily exposure to either rodent toys (cognitive stimulation) or running wheels (exercise), or daily acrobatic training for 6 weeks prior to and throughout behavioral testing. Controls were group housed, but did not receive enrichment. Spatial working and reference memory were tested in a water-escape motivated radial arm maze. Levels of the presynaptic protein synaptophysin were then measured in frontoparietal cortex, hippocampus, striatum, and cerebellum. Exercise, but not cognitive stimulation or acrobat training, improved spatial working memory relative to controls, despite the fact that both exercise and cognitive stimulation increased synaptophysin levels in the neocortex and hippocampus. These data suggest that exercise alone is sufficient to improve working memory, and that enrichment-induced increases in synaptophysin levels may not be sufficient to improve working memory in young females. Spatial reference memory was unaffected by enrichment. Acrobat training had no effect on memory or synaptophysin levels, suggesting a minimal contribution of motor learning to the mnemonic and neuronal benefits of enrichment. These results provide the first evidence that different elements of the enriched environment have markedly distinct effects on spatial memory and synaptic alterations.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.