دانلود مقاله ISI انگلیسی شماره 77238
عنوان فارسی مقاله

یک رژیم غذایی با فروکتوز بالا باعث اختلال در حافظه فضایی در موش صحرایی نر می شود

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77238 2009 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
A high fructose diet impairs spatial memory in male rats
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 92, Issue 3, October 2009, Pages 410–416

کلمات کلیدی
ماز آبی؛ تری گلیسیرید
پیش نمایش مقاله
پیش نمایش مقاله یک رژیم غذایی با فروکتوز بالا باعث اختلال در حافظه فضایی در موش صحرایی نر می شود

چکیده انگلیسی

Over the past three decades there has been a substantial increase in the amount of fructose consumed by North Americans. Recent evidence from rodents indicates that hippocampal insulin signaling facilitates memory and excessive fructose consumption produces hippocampal insulin resistance. Based on this evidence, the present study tested the hypothesis that a high fructose diet would impair hippocampal-dependent memory. Adult male Sprague–Dawley rats (postnatal day 61) were fed either a control (0% fructose) or high fructose diet (60% of calories). Food intake and body mass were measured regularly. After 19 weeks, the rats were given 3 days of training (8 trials/day) in a spatial version of the water maze task, and retention performance was probed 48 h later. The high fructose diet did not affect acquisition of the task, but did impair performance on the retention test. Specifically, rats fed a high fructose diet displayed significantly longer latencies to reach the area where the platform had been located, made significantly fewer approaches to that area, and spent significantly less time in the target quadrant than did control diet rats. There was no difference in swim speed between the two groups. The retention deficits correlated significantly with fructose-induced elevations of plasma triglyceride concentrations. Consequently, the impaired spatial water maze retention performance seen with the high fructose diet may have been attributable, at least in part, to fructose-induced increases in plasma triglycerides.

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