دانلود مقاله ISI انگلیسی شماره 77242
عنوان فارسی مقاله

آروماتاز عصبی اکتساب حافظه فضایی از طریق نفوذ در هیپوکامپ خواننده زن را تسریع می کند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77242 2004 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Neural aromatization accelerates the acquisition of spatial memory via an influence on the songbird hippocampus
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Hormones and Behavior, Volume 45, Issue 4, April 2004, Pages 250–258

کلمات کلیدی
استروژن؛ تستوسترون؛ آروماتاز؛ فنچ گورخری؛ دی هیدروتستوسترون؛ محل تماس دو عصب
پیش نمایش مقاله
پیش نمایش مقاله آروماتاز عصبی اکتساب حافظه فضایی از طریق نفوذ در هیپوکامپ خواننده زن را تسریع می کند

چکیده انگلیسی

Circulating estrogens affect the neural circuits that underlie learning and memory in several vertebrates via an influence on the hippocampus. In the songbird hippocampus local estrogen synthesis due to the abundant expression of aromatase may modulate hippocampal function including spatial memory performance. Here, we examined the effect of estradiol, testosterone, and dihydrotestosterone on the structure and function of the songbird hippocampus. Adult male zebra finches were castrated, implanted with one of these steroids or a blank implant, and trained on a spatial memory task. The rate of acquisition and overall performance on this task was recorded by direct observation. The size and density of cells in the hippocampus and its volume were measured. Estradiol-treated birds learned the task more rapidly than any other group. Although testosterone- and blank-implanted birds did learn the task, we found no evidence of learning in dihydrotestosterone-implanted subjects. Cells in the rostral hippocampus were larger in estradiol- and testosterone-treated birds relative to other groups. A corresponding decrease in the density of cells was apparent in estradiol-implanted subjects relative to all other groups. These data suggest that estradiol may accelerate the acquisition of a spatial memory task and increase the size of neurons in the rostral hippocampus. Since testosterone-mediated changes in acquisition and cell size were similar to those of estradiol, but not dihydrotestosterone, we conclude that neural aromatization of testosterone to estrogen is responsible for effects on the structure and function of the songbird hippocampus.

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