دانلود مقاله ISI انگلیسی شماره 77251
عنوان فارسی مقاله

اداره امور بعد از آموزش هورمون آزاد کننده کورتیکوتروپین (CRH) حفظ یک حافظه فضایی از طریق یک مکانیزم نورآدرنرژیک در موش صحرایی نر را افزایش می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77251 2008 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Post-training administration of corticotropin-releasing hormone (CRH) enhances retention of a spatial memory through a noradrenergic mechanism in male rats
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 89, Issue 4, May 2008, Pages 370–378

کلمات کلیدی
هورمون آزاد کننده کورتیکوتروپین؛ پروپرانولول؛ حافظه؛ نورآدرنرژیک
پیش نمایش مقاله
پیش نمایش مقاله اداره امور بعد از آموزش هورمون آزاد کننده کورتیکوتروپین (CRH) حفظ یک حافظه فضایی از طریق یک مکانیزم نورآدرنرژیک در موش صحرایی نر را افزایش می دهد

چکیده انگلیسی

Hormones released in response to stress play important roles in cognition. In the present study, the effects of the stress peptide, corticotropin-releasing hormone (CRH), on spatial reference memory were assessed following post-training administration. Adult Long-Evans male rats were trained for 6 days on a standard water maze task of reference memory in which animals must learn and remember the fixed location of a hidden, submerged platform. Each day, immediately following three training trials, rats received bilateral infusions of CRH into the lateral ventricles over a range of doses (0.1, 0.33, 1.0, 3.3 μg) or a vehicle solution. Post-training infusions of CRH improved retention as indicated by significantly shorter latencies and path lengths to locate the hidden platform on the first training (retention) trial of days 2 and 3. Additionally, post-training administration of CRH increased spatial bias during probe trials as measured by proximity to the platform location. CRH did not enhance performance on retention or probe trials when administered 2 h after daily training indicating that CRH facilitated consolidation specifically. The effects of CRH were attenuated by intraventricular co-administration of the beta-adrenergic antagonist, propanolol, at bilateral doses that had no effect on retention alone (0.1, 1.0 μg). Results indicate that post-training administration of CRH enhanced spatial memory as measured in a water maze, and this effect was mediated, at least partly, by a noradrenergic mechanism.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.