دانلود مقاله ISI انگلیسی شماره 77271
عنوان فارسی مقاله

گیرنده های NMDA و کانال های کلسیم وابسته به ولتاژ جنبه های مختلف کسب و حفظ وظیفه حافظه فضایی را تعدیل می کند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77271 2004 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
NMDA receptors and voltage-dependent calcium channels mediate different aspects of acquisition and retention of a spatial memory task
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 81, Issue 2, March 2004, Pages 105–114

کلمات کلیدی
تقویت طولانی مدت - حافظه فضایی؛ یادگیری فضایی
پیش نمایش مقاله
پیش نمایش مقاله گیرنده های NMDA و کانال های کلسیم وابسته به ولتاژ جنبه های مختلف کسب و حفظ وظیفه حافظه فضایی را تعدیل می کند

چکیده انگلیسی

Activity dependent calcium entry into neurons can initiate a form of synaptic plasticity called long-term potentiation (LTP). This phenomenon is considered by many to be one possible cellular mechanism underlying learning and memory. The calcium entry that induces this phenomenon can occur when N-methyl-d-aspartate receptors (NMDARs) and/or voltage-dependent calcium channels (VDCCs) are activated. While much is known about synaptic plasticity and the mechanisms that are triggered by activation of these two Ca2+ channels, it is unclear what roles they play in learning. To better understand the role activation of these channels may play in learning we systemically administered pharmacological antagonists to block NMDARs, VDCCs, or both during training trials and retention tests in a radial arm maze task. Wistar rats injected with the NMDAR antagonist MK-801 (0.1 mg/kg) were impaired in the acquisition of this task. In contrast, rats injected with verapamil (10 mg/kg), an antagonist to VDCCs, acquired the task at the same rate as control animals, but were impaired on a 10-day retention test. A group of animals injected with both antagonists were unable to learn the task. The results suggest that each of the calcium channels and the processes they trigger are involved in a different stage of memory formation or expression.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.