دانلود مقاله ISI انگلیسی شماره 77295
عنوان فارسی مقاله

غنی سازی حافظه فضایی و سطح سیناپتوفیزین در موش های ماده سالمندان را افزایش می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77295 2003 12 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 24, Issue 4, July–August 2003, Pages 615–626

کلمات کلیدی
غنی سازی محیط زیست؛ حافظه مرجع فضایی؛ سیناپتوفیزین؛ هیپوکامپ؛ قشر
پیش نمایش مقاله
پیش نمایش مقاله غنی سازی حافظه فضایی و سطح سیناپتوفیزین در موش های ماده سالمندان را افزایش می دهد

چکیده انگلیسی

The present study tested whether environmental enrichment can reduce age-related spatial reference memory deficits and alter synaptic protein levels in aged female mice. Female C57BL/6 mice, (4 or 27–28 months), were tested in spatial and cued Morris water maze tasks. Prior to (14 days) and during testing, a subset of aged females was exposed to rodent toys and running wheels for 3 h per day. The remaining aged females were group housed but were not exposed to enriching objects. At the conclusion of testing, levels of the presynaptic protein synaptophysin were measured in hippocampus and frontoparietal cortex. Enrichment improved spatial memory acquisition; relative to young controls, aged enriched females performed similarly, whereas aged control females were impaired. Enrichment also accelerated the development of a spatial bias in spatial probe trials. In contrast, the cued task was not significantly affected by enrichment. Hippocampal and cortical synaptophysin levels were increased in aged enriched females relative to young and aged controls. These data suggest that environmental enrichment can be a potent cognitive enhancer for aged females and suggests a potential neurobiological mechanism of this effect.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.