دانلود مقاله ISI انگلیسی شماره 77342
عنوان فارسی مقاله

نقصان ادراک حرکتی در سندرم داون

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77342 2015 7 صفحه PDF سفارش دهید 5110 کلمه
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Motion perception deficit in Down Syndrome
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 75, August 2015, Pages 214–220

کلمات کلیدی
سندرم داون - بیماری آلزایمر؛ ادراک حرکت؛ جریان بینایی
پیش نمایش مقاله
پیش نمایش مقاله نقصان ادراک حرکتی در سندرم داون

چکیده انگلیسی

It is a well established fact that Down Syndrome (DS) individuals have a tendency to develop Alzheimer's disease (AD) (Lott, I.T., Head, E., 2005. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol. Aging 26, 383–389). They have therefore been proposed as a model to study the pre-dementia stage of Alzheimer's (Mann, D.M., 1988. The pathological association between Down syndrome and Alzheimer disease. Mech. Ageing Dev. 43, 99–136). One of the specific deficits exhibited by AD patients is optic flow motion perception (Tetewsky, S.J., Duffy, C.J., 1999. Visual loss and getting lost in Alzheimer's disease. Neurology 52, 958–965), but there are no corresponding systematic studies in DS individuals. We performed sensitivity measurements to optic flow with Visual Evoked Potentials (VEP) and psychophysical techniques in a group of young DS participants with mild mental retardation and without significant Alzheimer's clinical symptoms. We found a significant reduction in direction discrimination sensitivity to optic flow (random dots moving in radial, rotational and translational trajectories) in DS participants compared to mental age-matched controls, while their sensitivity to direction of control moving stimuli (sinusoidal gratings) was similar to age-matched controls. Measurements of Visual Evoked Potentials (VEP) showed no response to optic flow, although the response to control stimuli (contrast-reversal checkerboard patterns) was significant. Overall, our results show a selective and substantial deficit in the perception of optic flow motion and a corresponding suppression of electroencephalographic activity in DS individuals, thus establishing a further common trait between Down Syndrome and Alzheimer's disease.

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