دانلود مقاله ISI انگلیسی شماره 77343
عنوان فارسی مقاله

تداوم حضور به نفع یک درمان آنتی اکسیدانی در کودکان و نوجوانان با سندرم داون

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77343 2015 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Persistence of the benefit of an antioxidant therapy in children and teenagers with Down syndrome
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Research in Developmental Disabilities, Volumes 45–46, October–November 2015, Pages 14–20

کلمات کلیدی
سندرم داون - گونه های فعال اکسیژن ؛ استرس اکسیداتیو؛ درمان آنتی اکسیدانی اثر تداوم
پیش نمایش مقاله
پیش نمایش مقاله تداوم حضور به نفع یک درمان آنتی اکسیدانی در کودکان و نوجوانان با سندرم داون

چکیده انگلیسی

This study examined the effect of an antioxidant intervention in biomarkers of inflammation and oxidative stress (OS) in the blood of Down syndrome (DS) children and teenagers during four different stages. A control group was composed by healthy children (n = 18), assessed once, and a Down group composed by DS patients (n = 21) assessed at the basal period (t0), as well as after 6 months of antioxidant supplementation (t1), after 12 months (after interruption of the antioxidant intervention for 6 months) (t2), and again after further 6 months of antioxidant supplementation (t3). Biomarkers of inflammation (myeloperoxidase activity – MPO and levels of IL-1β and TNF-α) and OS (thiobarbituric acid reactive substances – TBARS, protein carbonyls – PC), reduced glutathione (GSH), uric acid (UA) and vitamin E levels, as well as antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and gamma-glutamyltransferase (GGT) activities, were measured after each period. After the antioxidant supplementation, the activities of SOD, CAT, GPx, GR, GGT and MPO were downregulated, while TBARS contents were strongly decreased, the contents of GSH and vitamin E were significantly increased, and no changes in G6PD and GST activity as well as in UA and PC levels were detected. After the interruption of the antioxidant therapy for 6 months, DS patients showed elevated GPx and GGT activities and also elevated UA and TBARS levels. No changes in SOD, CAT, GR, GST, G6PD and MPO activities as well as in GSH, vitamin E, PC, TNF-α and IL-1β levels were detected. The results showed that the antioxidant intervention persistently attenuated the systemic oxidative damage in DS patients even after a relatively long period of cessation of the antioxidant intervention.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.