دانلود مقاله ISI انگلیسی شماره 77433
عنوان فارسی مقاله

زندگی مشترک با جفت داخل قفس ملانوم B16F10 ، رفتار و فنوتیپ سلولهای دندریتیک در موش

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77433 2009 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Cohabitation with a B16F10 melanoma-bearer cage mate influences behavior and dendritic cell phenotype in mice
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Brain, Behavior, and Immunity, Volume 23, Issue 4, May 2009, Pages 558–567

کلمات کلیدی
استرس روانی؛ سلولهای دندریتیک؛ حساسیت به تاخیر افتاده ازدیاد ؛ عصبی ایمنی شناختی
پیش نمایش مقاله
پیش نمایش مقاله زندگی مشترک با جفت داخل قفس ملانوم B16F10 ، رفتار و فنوتیپ سلولهای دندریتیک در موش

چکیده انگلیسی

This study evaluated the effects of cohabitation with a B16F10 melanoma-bearer cage mate on behavior and immune functions in mice. Five different experiments were conducted. In each of them, the female mice were divided into two groups: control and experimental. One mouse of each control pair was kept undisturbed and called “companion of health partner” (CHP). One mouse of each experimental pair was inoculated with B16F10 cells and the other, the subject of this study, was called “companion sick partner” (CSP). On Day 20 of cohabitation, behavior and immune parameters from CHP and CSP mice were analyzed. In comparison to the CHP, the CSP mice: (1) presented an increased general locomotion in the open field and a decreased exploration time and number of entries in the plus-maze open arms; (2) had an enhanced expression of the CD80 costimulatory molecule on Iab+CD11c+ spleen cells, but no differences were found on lymph nodes cells; (3) presented an altered differentiation of bone marrow cells in the presence of GM-CSF, IL-4, and LPS in vitro, resulting in a lower percentage of Iab+CD80+ cells; (4) had a deficit in the establishment of a Delayed Type of Hypersensitivity to ovalbumin, which was associated to an in vitro proliferation of an IL-10-producing lymphocyte subpopulation after ovalbumin stimulation. Corticosterone levels detected on Day 20 of cohabitation were similar in CHP and CSP mice. It is shown here that DCs phenotype in mice is affected by conditions associated with behavioral alterations indicative of an anxiety-like state induced by the cohabitation with a tumor-bearer conspecific. This phenomenon occurred probably through a nondependent corticosterone mechanism.

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