دانلود مقاله ISI انگلیسی شماره 77739
عنوان فارسی مقاله

اثر ترکیبی از دو ژن خطر ابتلا به آلزایمر در فعالیت تمپورال داخلی در طول توجه اجرایی در افراد جوان

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77739 2014 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
A combined effect of two Alzheimer's risk genes on medial temporal activity during executive attention in young adults
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 56, April 2014, Pages 1–8

کلمات کلیدی
توجه اجرایی؛ لوب تمپورال داخلی
پیش نمایش مقاله
پیش نمایش مقاله اثر ترکیبی از دو ژن خطر ابتلا به آلزایمر در فعالیت تمپورال داخلی در طول توجه اجرایی در افراد جوان

چکیده انگلیسی

A recent history of failed clinical trials suggests that waiting until even the early stages of onset of Alzheimer's disease may be too late for effective treatment, pointing to the importance of early intervention in young people. Early intervention will require markers of Alzheimer's risk that track with genotype but are capable of responding to treatment. Here, we sought to identify a functional MRI signature of combined Alzheimer's risk imparted by two genetic risk factors. We used a task of executive attention during fMRI in participants genotyped for two Alzheimer's risk alleles: APOE-ε4 and CLU-C. Executive attention is a sensitive indicator of the progression of Alzheimer's even in the early stages of mild cognitive impairment, but has not yet been investigated as a marker of Alzheimer's risk in young adults. Functional MRI revealed that APOE-ε4 and CLU-C had an additive effect on brain activity such that increased combined genetic risk was associated with decreased brain activity during executive attention, including in the medial temporal lobe, a brain area affected early in Alzheimer's pathogenesis.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.