دانلود مقاله ISI انگلیسی شماره 77960
عنوان فارسی مقاله

تنفر TNF-α، IL-6 و سطوح نورآدرنالین در بیماران مبتلا به اختلال وسواس را تحت تاثیر قرار می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
77960 2010 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Disgust affects TNF-α, IL-6 and noradrenalin levels in patients with obsessive–compulsive disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 35, Issue 6, July 2010, Pages 906–911

کلمات کلیدی
اختلال وسواسی-اجباری؛ تحریک؛ تنفر؛ اعصاب و غدد
پیش نمایش مقاله
پیش نمایش مقاله تنفر TNF-α،  IL-6 و سطوح نورآدرنالین در بیماران مبتلا به اختلال وسواس را تحت تاثیر قرار می دهد

چکیده انگلیسی

Neurobiological research of obsessive–compulsive disorder (OCD) has rarely taken in account the context dependent evocation of obsessive–compulsive symptoms. To bypass this obstacle, this study investigated neurobiological parameters during a standardized disgust provocation paradigm in patients with OCD and healthy controls. Ten OCD patients and 10 healthy controls were exposed to 9 disgust related items using a standardized provocation paradigm. Catecholamines and cortisol in plasma and lipopolysaccharide (LPS) stimulated levels of TNF-α and IL-6 by peripheral leucocytes were assessed along with severity of obsessive–compulsive symptoms, disgust, and anxiety levels using Visual Analogue Scales prior, during and after a provocation paradigm. Noradrenalin levels increased, while LPS stimulated TNF-α and IL-6 by peripheral leucocytes decreased during exposure to disgust related objects in OCD patients but not in healthy controls. Cortisol levels were not affected by exposure neither in patients nor in controls, but overall cortisol levels of OCD patients were increased compared to controls. In conclusion, our data suggests that symptom provocation in OCD patients with contamination fear is accompanied by alterations in the immune and neuroendocrine systems but does not affect cortisol levels.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.