دانلود مقاله ISI انگلیسی شماره 78132
عنوان فارسی مقاله

کارآزمایی تصادفی باز اثرات آریپیپرازول در مقابل ریسپریدون در شناخت اجتماعی در اسکیزوفرنی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
78132 2014 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Open, randomized trial of the effects of aripiprazole versus risperidone on social cognition in schizophrenia
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 24, Issue 4, April 2014, Pages 575–584

کلمات کلیدی
آریپیپرازول؛ عصبی شناختی ؛ ریسپریدون؛ اسکیزوفرنیا؛ شناخت اجتماعی
پیش نمایش مقاله
پیش نمایش مقاله کارآزمایی تصادفی باز اثرات آریپیپرازول در مقابل ریسپریدون در شناخت اجتماعی در اسکیزوفرنی

چکیده انگلیسی

To date, only few studies have examined the impact of medication on social cognition and none have examined the effects of aripiprazole in this respect. The goal of this 8-week, randomized, multicenter, open-label study was to examine the effects of aripiprazole and risperidone on social cognition and neurocognition in individuals with schizophrenia. Eighty schizophrenia patients (DSM-IV-TR) aged 16–50 years were administered multiple computerized measures of social cognition and neurocognition including reaction times at baseline and the end of week 8. Social functioning was mapped with the Social Functioning scale and Quality of Life scale. The study ran from June 2005 to March 2011. Scores on social cognitive and neurocognitive tests improved with both treatments, as did reaction time. There were few differences between the two antipsychotics on (social) cognitive test-scores. The aripiprazole group performed better (more correct items) on symbol substitution (P=.003). Aripiprazole was also superior to risperidone on reaction time for emotional working memory and working memory (P=.006 and P=.023, respectively). Improvements on these tests were correlated with social functioning. In conclusion, aripiprazole and risperidone showed a similar impact on social cognitive test-scores. However, aripiprazole treatment produced a greater effect on patients' processing speed compared to risperidone, with these improvements being associated with concurrent improvements in social functioning. Further research on the long-term effects of aripiprazole on cognition is warranted.

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