علائم افسردگی و ارتباط نارضایتی از بدن در زنان مبتلا با سندرم تخمدان پلی کیستیک

Objective One publication reported that lower body satisfaction and lower education were independent predictors of depression in polycystic ovary syndrome (PCOS) in women. This study replicates that analysis using different instruments, and adds androgen levels to the model. Methods Cross-sectional analysis of questionnaires (Quick Inventory of Depressive Symptomatology-Self-Report, Body Esteem Scale) and serum androgens from a community cohort with (n=94) and without (n=96) PCOS, matched by BMI category. Non-parametric tests, Spearman correlations, and negative binomial regression models were analyzed. Results Depression symptoms were common (40–60% in lean, overweight and obese BMI categories) in the PCOS cohort, albeit generally of mild severity. The PCOS women had similar depression symptom severity (P > .20) and similar body dissatisfaction (P ≥ .25) as the regularly cycling women in total and stratified by BMI category. In both the PCOS and non-PCOS cohorts, depression symptom severity was positively correlated with dissatisfaction with physical appearance and physical conditioning (P < .02). Body dissatisfaction (especially perception of physical conditioning) was strongly associated with more severe depression symptoms in non-obese PCOS women (BMI < 30, P < .04) before and after controlling for age, testosterone and free testosterone. In contrast, for obese women with PCOS, depression was unrelated to body dissatisfaction after controlling for age. Conclusions Among non-obese PCOS women, their subjective body image was strongly associated with the severity of their depression symptoms. Most of the obese PCOS cohort had low body satisfaction and depression symptoms, therefore individual differences in the body dissatisfaction scores were not helpful in identifying depression symptom severity. Neither testosterone nor free testosterone was associated with depression symptom severity in PCOS women after controlling for body dissatisfaction and age.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age women [1]. Approximately 6.5% of women of reproductive age have PCOS [2] and [3], which is characterized by irregular or absent menstrual periods and hyperandrogenic manifestations such as acne and hirsutism [4]. The prevalence of depression and depression symptoms is significant in women with PCOS (29% [5] to 50% [6] in small cohorts). In one recent report, women with PCOS were found to have a 3.8 times higher lifetime incidence of depressive episodes (per clinical interviews) than age-, but not BMI-, matched women [7].