دانلود مقاله ISI انگلیسی شماره 52515
ترجمه فارسی عنوان مقاله

بهینه سازی فرمولاسیون نانوذرات کنترل شده هوراکلورید وراپامیل با استفاده از شبکه های عصبی مصنوعی با الگوریتم ژنتیک و روش سطح پاسخ

عنوان انگلیسی
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
52515 2015 10 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Journal of Pharmaceutics and Biopharmaceutics, Volume 94, August 2015, Pages 170–179

چکیده انگلیسی

This study was performed to optimize the formulation of polymer–lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimization were conducted based on a spherical central composite design. Three formulation factors, i.e., weight ratio of drug to lipid (X1), and concentrations of Tween 80 (X2) and Pluronic F68 (X3), were chosen as independent variables. Drug loading efficiency (Y1) and mean particle size (Y2) of PLN were selected as dependent variables. The predictive performance of artificial neural networks (ANN) and the response surface methodology (RSM) were compared. As ANN was found to exhibit better recognition and generalization capability over RSM, multi-objective optimization of PLN was then conducted based upon the validated ANN models and continuous genetic algorithms (GA). The optimal PLN possess a high drug loading efficiency (92.4%, w/w) and a small mean particle size (∼100 nm). The predicted response variables matched well with the observed results. The three formulation factors exhibited different effects on the properties of PLN. ANN in coordination with continuous GA represent an effective and efficient approach to optimize the PLN formulation of VRP with desired properties.