افزایش سن و ارتباطات عصبی حافظه مبدا : سازماندهی مجدد کاربردی
|کد مقاله||سال انتشار||تعداد صفحات مقاله انگلیسی||ترجمه فارسی|
|71079||2012||-406 صفحه PDF||سفارش دهید|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Neurobiology of Aging, Volume 33, Issue 2, February 2012, Pages 425.e3–425.e18
Behavioral evidence suggests that memory for context (i.e., source memory) is more vulnerable to age-related decline than item memory. It is not clear, however, whether this pattern reflects a specific age-related deficit in context memory or a more general effect of task difficulty. In the present study, we used event-related functional magnetic resonance imaging (fMRI) with healthy younger and older adults to dissociate the effects of age, task (item vs. source memory), and task difficulty (1 vs. 2 study presentations) on patterns of blood oxygen level-dependent (BOLD) signal changes during memory retrieval. Behavioral performance was similar in both age groups, but was sensitive to task and difficulty (item > source; easy > difficult). Data-driven multivariate analyses revealed age differences consistent with age-related overrecruitment of frontoparietal regions during difficult task conditions, and age-related functional reorganization in bilateral frontal and right-lateralized posterior regions that were sensitive to difficulty in younger adults, but to task (i.e., context demand) in older adults. These findings support the hypothesis of a specific context memory deficit in older adults.