دانلود مقاله ISI انگلیسی شماره 75395
ترجمه فارسی عنوان مقاله

حملات هراس، ناشی از دوگزاپرام و ارتفاع سطح کورتیزول

عنوان انگلیسی
Doxapram-induced panic attacks and cortisol elevation
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
75395 2005 9 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 133, Issues 2–3, 28 February 2005, Pages 253–261

ترجمه کلمات کلیدی
بخشی دوگزاپرام؛ حملات هراس؛ تحریک تنفسی؛ کورتیزول
کلمات کلیدی انگلیسی
Doxapram; Panic attacks; Ventilatory stimulant; Cortisol
پیش نمایش مقاله
پیش نمایش مقاله  حملات هراس، ناشی از دوگزاپرام و ارتفاع سطح کورتیزول

چکیده انگلیسی

Numerous agents with differing biological properties and central nervous system (CNS) effects can induce panic attacks in predisposed individuals. A potential explanation of this finding is that panic disorder patients are more likely to panic than normal control subjects when given a panicogen due to an excessive fear response to somatic arousal. We test this hypothesis by using doxapram, a panicogen with minimal CNS effects, to induce panic in patients and control subjects. Doxapram was given to six subjects with panic disorder with or without agoraphobia and four healthy volunteers. Measures comprised the Acute Panic Inventory, the Borg Exertion scale, the 10-point Anxiety Scale, the 10-point Apprehension Scale, cortisol, prolactin, and MHPG, all obtained at baseline and multiple time points after the doxapram infusion. All panic disorder patients panicked with doxapram, whereas no control subjects had a panic attack. Panic patients had similar levels of breathlessness with doxapram compared with control subjects. Although panic patients had higher levels of anxiety and apprehension, these did not change significantly with doxapram compared with control levels. Doxapram led to similar increases in cortisol and prolactin in both groups, and MHPG was consistently elevated in panic patients, but unaffected by doxapram. These results show that doxapram is a useful panicogen in the study of panic disorder. Since the panic patients and control subjects had similar levels of physiological and psychological arousal, but the panic patients were more likely to have a panic attack, this lends support to the concept of a sensitized fear network in panic disorder patients.