نتایج مزمن استرس روانی- اجتماعی در حساس سازی محور HPA به عوامل استرس زای حاد مختلف با وجود کاهش آدرنال در شرایط واکنش آزمایشگاهی ACTH

Taken together, we show that chronic psychosocial stressor exposure impairs in vitro ACTH responsiveness of both the left and right adrenal glands, whereas it increases adrenal responsiveness to an acute heterotypic stressor in vivo. This suggests that an additional factor present during acute stressor exposure in vivo rescues left and right adrenal ACTH sensitivity, or itself acts as CORT secretagogue in chronically stressed CSC mice.