دانلود مقاله ISI انگلیسی شماره 124921
عنوان انگلیسی
Tokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with β-amyloid in rats
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
124921 2018 6 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Pharmacological Sciences, Volume 136, Issue 3, March 2018, Pages 149-154

پیش نمایش مقاله
پیش نمایش مقاله

چکیده انگلیسی

Previously, we reported that ovariectomy (OVX) combined with β-amyloid peptide (Aβ) impaired spatial memory by decreasing extracellular acetylcholine (ACh) levels in the dorsal hippocampus. Here, we investigated the effect of tokishakuyakusan (TSS), a Kampo medicine, on the impairment of spatial memory induced by OVX combined with Aβ in rats. Repeated administration of TSS (300 mg/kg, p.o.) significantly decreased the number of errors in the eight-arm radial maze test. Though TSS had no effect on extracellular ACh levels at baseline, TSS significantly increased extracellular ACh levels in the dorsal hippocampus. These results suggest that TSS improves the impairment of spatial memory induced by OVX combined with Aβ by (at least in part) increasing extracellular ACh levels in the dorsal hippocampus.