دانلود مقاله ISI انگلیسی شماره 142708
ترجمه فارسی عنوان مقاله

سیناپس وابسته به فعالیت به سیگنال هسته ای

عنوان انگلیسی
Activity-dependent synapse to nucleus signaling
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
142708 2017 22 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 138, February 2017, Pages 78-84

پیش نمایش مقاله
پیش نمایش مقاله  سیناپس وابسته به فعالیت به سیگنال هسته ای

چکیده انگلیسی

The unique polarity of neurons requires that synaptic inputs are relayed to the nucleus to trigger changes in gene expression. This long distance signaling process is crucial for the function and survival of neuronal circuits. To that end, neurons have developed multiple modes of signal transmission from the synapse to the nucleus. In this review, we summarize the latest research on activity-dependent movement and nuclear import of postsynaptic proteins that modulate neuronal plasticity. We also focus on the mechanism of active transport as well as the role of importins in mediating nuclear import of the postsynaptic proteins. Finally, we briefly discuss the role of synapse to nucleus signaling in the context of transcription-dependent plasticity and conclude by describing future challenges in this field of research.