The developed simulation model, implemented in a suitable MatLab computer tool, is experimentally validated; the main results of the validation process are discussed in this paper. Moreover, in order to show the potential of the presented building integrated collector prototype and of the related simulation tool, a suitable case study is developed. It refers to a residential unit of a multi-floor building where the prototype collectors are integrated on the South façade. Simulations are carried out for 2 building envelope weights and 9 different weather zones. Interesting outcomes from the energy, economic, environmental, and comfort point of views are obtained.