دانلود مقاله ISI انگلیسی شماره 141559
ترجمه فارسی عنوان مقاله

آیا پسوریازیس یک بیماری روده است؟ درمان موفق با اسید های صفراوی و بیوفلاوونویدها نشان می دهد این است

عنوان انگلیسی
Is psoriasis a bowel disease? Successful treatment with bile acids and bioflavonoids suggest it is
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
141559 2018 32 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Clinics in Dermatology, Available online 28 March 2018

پیش نمایش مقاله
پیش نمایش مقاله  آیا پسوریازیس یک بیماری روده است؟ درمان موفق با اسید های صفراوی و بیوفلاوونویدها نشان می دهد این است

چکیده انگلیسی

The gut is the largest lymphoid organ in the body. The human microbiome is composed of trillions of bacteria. The DNA of these bacteria dwarfs the human genome. Diet and ethanol can cause rapid shifts in the number and types of bacteria in the gut. The psoriatic microbiome is similar to that seen in alcoholics; there is a decrease in bacterial diversity and overgrowth of bacteria in the small bowel. Psoriatics often have liver disease and deficiencies in bile acids. Psoriasis is a disease characterized by a leaky gut. All of the comorbidities of this disease are due to systemic endotoxemia. Bacterial peptidoglycans absorbed from the gut have direct toxic effects on the liver and skin. Their absorption as well as endotoxin absorption must be eliminated to treat psoriasis successfully. Endotoxin absorption is markedly increased by ethanol and peppers. Bioflavinoids, such as quercetin and citrus bioflavonoids, prevent this absorption. Bile acids, given orally, break up endotoxin in the intestinal lumen. Pathogens, including Helicobacter pylori and Streptococcus pyogenes, must be eliminated with antimicrobial therapy for any treatment to work. A complete protocol for curing psoriasis is provided.